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For other uses, see. Sildenafil, sold as sildenafil the brand name. Viagra among others, is a medication used to treat sildenafil erectile dysfunction and pulmonary arterial hypertension. 3, its effectiveness for treating sexual dysfunction in sildenafil women has not been demonstrated. 3, common side effects include headaches and heartburn, as well as flushed skin. Caution is advised in those who have cardiovascular disease. Rare but serious side effects include prolonged erections, which can lead to damage to the penis, and sudden-onset hearing loss. Sildenafil should not be taken by people who take nitrates such as nitroglycerin (glycerin trinitrate as this may result in a severe and potentially fatal drop in blood pressure. 3, sildenafil acts by inhibiting cGMP-specific phosphodiesterase type 5 (phosphodiesterase 5, PDE5 an enzyme that promotes degradation of cGMP, which regulates blood flow in the penis. Pfizer scientists, andrew Bell, David Brown, and Nicholas Terrett originally discovered sildenafil as a treatment for various cardiovascular disorders. 4 5, since becoming available in 1998, sildenafil has been a common treatment for erectile dysfunction; its primary competitors are tadalafil (trade name Cialis) and vardenafil (Levitra). Contents Medical uses Pfizer Viagra tablet in the trademark blue diamond shape Sexual dysfunction The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus. 6 Antidepressant-associated sexual dysfunction Tentative evidence suggests that sildenafil may help men who experience antidepressant -induced erectile dysfunction. 7 Pulmonary hypertension While sildenafil improves some markers of disease in people with pulmonary arterial hypertension, it does not appear to affect the risk of death or serious side effects as of 2014. 8 Raynaud's phenomenon Sildenafil and other PDE5 inhibitors are used off-label to alleviate vasospasm and treat severe ischemia and ulcers in fingers and toes for people with secondary Raynaud's phenomenon ; 9 10 these drugs have moderate efficacy for reducing the frequency and duration. 9 As of 2016, their role more generally in Raynaud's was not clear. 10 Adverse effects In clinical trials, the most common adverse effects of sildenafil use included headache, flushing, indigestion, nasal congestion, and impaired vision, including photophobia and blurred vision. 2 Some sildenafil users have complained of seeing everything tinted blue ( cyanopsia ). 11 Some complained of blurriness and loss of peripheral vision. In July 2005, the FDA found that sildenafil could lead to vision impairment in rare cases 12 and a number of studies have linked sildenafil use with non-arteritic anterior ischemic optic neuropathy. 13 Rare but serious adverse effects found through postmarketing surveillance sildenafil include prolonged erections, severe low blood pressure, myocardial infarction (heart attack ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss. 2 In October 2007, the FDA announced that the labeling for all PDE5 inhibitors, including sildenafil, required a more prominent warning of the potential risk of sudden hearing loss. 14 Interactions Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection. Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects. Those using protease inhibitors are recommended to limit their use of sildenafil to no more than one 25 mg dose every 48 hours. 2 Other drugs that interfere with the metabolism of sildenafil include erythromycin and cimetidine, both of which can also lead to prolonged plasma half-life levels. The use of sildenafil and an 1 blocker (typically prescribed for hypertension or for urologic conditions, such as benign prostatic hypertrophy ) at the same time may lead to low blood pressure, but this effect does not occur if they are taken at least. 15 Contraindications Contraindications include: 2 :11 Concomitant use of nitric oxide donors, organic nitrites and nitrates, 16 such as: Concomitant use of soluble guanylyl cyclase stimulators, such as riociguat Known hypersensitivity to sildenafil Sildenafil should not be used if sexual activity is inadvisable due. 18 Sildenafil's trade name, Viagra, is widely recognized in popular culture, and the drug's association with treating erectile dysfunction has led to its recreational use. 19 The reasons behind such use include the belief that the drug increases libido, improves sexual performance, 19 or permanently increases penis size. 20 Studies on the effects of viagra when used recreationally are limited, but suggest it has little effect when used by those not suffering from erectile dysfunction. In one study, a 25-mg dose was shown to cause no significant change in erectile quality, but did reduce the postejaculatory refractory time. 21 This study also noted a significant placebo effect in the control group.

Sildenafil cream

Common Questions and Answers about Sildenafil sildenafil cream cream viagra, please tell me one brand name of mild corticosteroid cream so that i will use that cream. And also applying this cream on swelling areas will solve my problem? Read More, there was no change in my lifestyle for last one month except applying 'Ketoconazole' anti-fungal shampoo and cream (only external use). Soon after I sildenafil cream noticed erectile dysfunction, I stopped taking the medicine. I wonder if this would have impact on my erection? Should I wait for a few weeks to see if I come back normal. Please advise whet should I do to cure this? Read More, he was diagnosed with pulmonary hypertension around March of this year by a cardiologist. Since then we have had him on sildenafil with regular check ups and heart scans to monitor his progress. During his latest check up his primary vet ran blood and urine and we discovered that he is in stage 3 renal failure and his kidneys are only working at about 20-30. Like most on this forum, I feel guilt for not having caught this sooner. Read More, viagra and Levitra Viagra and Levitra are also based on inhibitors that increase the blood flow to the penis, sildenafil and vardenafil respectively. Although different in appearance; Viagra is a blue diamond shape and levitra is round and yellow, both are similar and the effects of the erection tablets last on average four hours, though some studies suggest some benefit for up to 10 hours. One minute I am fine sildenafil cream then all of a sudden the pain hits me and then it goes away again. I have tried all the hemorriod cream etc. And they have not worked. Says it is an anual fissure but just not sure. How on earth are these things ever suppose to heal when you have a bowel movement everyday and probably open back the tear. Any feedback would be great. Read More, any cream can make gland cure i thought some part in the glanse blood flatted. Read More, also, dx about month ago with blepharochalasis upper eye lids - swelled nearly shut, they were creased in the middle of the lid, fat pads protruding, with associated telangiectasias. Using steroid cream now - helped a lot. Frequent right and left upper quad pain, left kidney pain, dark urine at times, and itching. All of this comes and goes. I thought I was having symptoms of portal hypertension but when bx came back stage 0, I started looking at what else. Read More sildenafil, tadalafil Hormone replacement: cortisol, estradiol, methylprednisolone, progesterone, testosterone Immunosuppressants: cyclosporine, sirolimus, tacrolimus HMG-CoA reductase inhibitors: atorvastatin, fluvastatin, lovastatin, simvastatin Opioids: alfentanil, fentanyl, sufentanil Selective serotonin reuptake inhibitors: fluvoxamine, sertraline Xanthine: theophylline. Read More, it came back low on the normal side. He prescribed a tes cream, i rub on a muscle everyday. Been using it for a year now and just tested at 828. I also take dhea, and several vitamins, but he said I was vitamin D deficient and told me to take 2000ui per day. I gotta say I feel great. Started back at the gym taking a pre-workout mix and feel like I did when I was. I highly encourage anyone that is middle aged gaining that waistline weight to get checked. Food and Drug Administration. Sildenafil, Tadalafil, Vardenafil - Labels updated with naion information. FDA Statement.

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